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.Gender differences in circulating bilirubin levels in relation to breast cancer risk.
The association between circulating serum bilirubin levels and breast cancer risk has not been reported extensively. In this study, we analyzed the distribution of serum bilirubin and its associations with breast cancer risk, among gender-specific subgroups of women. The participants were recruited from the Health Screening Center at the School of Medicine, Wuhan University, Wuhan, China from November 1996 to January 2002. Women with surgical intervention after the enrollment were excluded. The mean level of serum bilirubin was negatively associated with risk of all breast cancers in the total study population, with adjusted hazard ratios (HRs) per 1 mg/dL increase in serum bilirubin level of 0.82 [95% confidence interval (95% CI), 0.74-0.90]. The association was more pronounced in premenopausal women than in postmenopausal women. Further analyses suggested that the positive association was more prominent in estrogen receptor (ER) positive than in ER negative breast cancers. Serum bilirubin level was also associated with a significant protection against ductal carcinoma in situ (DCIS) (HR per 1 mg/dL increase in serum bilirubin level of 0.43, 95% CI, 0.19-0.96). The positive association was more prominent among women with low body mass index (BMI), in particular among overweight/obese women. Considering the independent effect on breast cancer risk in different subgroups, we found that serum bilirubin might be a potential common biomarker of early detection and prevention of breast cancers in women of different BMI levels.Kick off your boots and flip 0b46394aab
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